Knife Guy & Grate Guy...
Knife Guy and Grate Guy have some mean attacks, but you should be able to handle them. Focus your attention on Knife Guy and pound him until the two brothers team up, then hit Grate Guy. The best team for this fight is Mario, Geno, and Bowser (your new best friend). Equip someone with the Amulet you SHOULD have just received! Grate Guy is not nearly as vulnerable to Special Attacks as Knife Guy is, so once Knife Guy bites the dust you should stick to regular attacks.